Intrathecal stem cell therapy in Istanbul, step by step
What the intrathecal route is, why our medical team may select it for a neurological case, who performs the procedure, and what the day involves.
Intrathecal Stem Cell Therapy at Our Istanbul Clinic
This page explains what intrathecal stem cell therapy is, how our medical team plans it, and what treatment in Istanbul involves. It is general information rather than a treatment plan: suitability is confirmed only after our team has reviewed your diagnosis, your records, the alternatives open to you, and the goals you want treatment to support.
At a glance
Intrathecal Stem Cell Therapy at a glance
- Biological material
- A cell product placed into the cerebrospinal fluid. Our team can share the research specific to your condition and to the product proposed.
- How it is given
- By lumbar puncture. It is an invasive procedure, so it calls for specialist neurological review, procedural consent and monitoring afterwards.
- Where it sits today
- Studied across several neurological conditions, where evidence, eligibility and risk differ substantially; many uses remain investigational.
- Who it may suit
- That is decided case by case. This page explains the treatment; suitability is confirmed only after our medical team has reviewed your records.
Intrathecal access to the fluid around the spinal cord
Intrathecal administration is a lumbar procedure rather than another infusion. This visual shows the anatomy involved, the sterile technique it requires, and the recovery time we build into a visit.

Clinical context

Microscopic research viewIllustrative detail
- Precise anatomy
- The procedure reaches the cerebrospinal fluid below the end of the spinal cord, using defined landmarks or imaging support.
- Procedure-specific risk
- Bleeding, infection, headache, nerve symptoms, pressure, medication, and individual anatomy are assessed before we proceed.
- Why this route is used
- The rationale is placing the preparation close to the central nervous system, and our team explains what is known about that and what is still being studied.
What Is Intrathecal Stem Cell Therapy?
Intrathecal administration places the cell preparation into the cerebrospinal fluid, the clear fluid that surrounds the brain and spinal cord, through a lumbar puncture in the lower back. Some patients search for this as lumbar puncture stem cell therapy or as a spinal injection, and a spinal tap is the same procedure under an older name. It is done with a fine needle, under local anaesthetic, by a physician experienced in the technique.
The route is considered for neurological goals because the fluid it enters is already in contact with the central nervous system, so the preparation does not have to cross the barrier that protects the brain from the bloodstream. Being closer to the target is a reason to investigate a route; it is not a claim that it works better than another. Our medical team weighs it against the intravenous and intranasal routes for your case, and says which it would propose and why.
Before the procedure you have a specialist neurological review, and our team checks bleeding risk, anticoagulant medication, infection, spinal anatomy and pressure inside the skull. On the day the procedure is performed under sterile technique, and afterwards you rest flat and are observed for headache, back pain or any nerve symptom before discharge, with written aftercare instructions to take home. Send your imaging and specialist reports for a medical case review to find out whether this is a route we would propose for you.
How Intrathecal Stem Cell Therapy Works
These are the biological ideas intrathecal stem cell therapy is built on. How much of it applies to you depends on your diagnosis, the goals set during your case review, the route of administration and the rest of your clinical picture, which is what our medical team works through with you.
- Cerebrospinal fluid is in direct contact with the brain and spinal cord, so a preparation placed there does not have to cross the blood-brain barrier
- The interest is in the signals the cells release rather than in replacement of nerve tissue - biological messages passed to nearby cells, known as paracrine signalling
- Some of those signals are studied for the support they may give to nerve cells, an area called neurotrophic signalling
- Inflammation inside the nervous system is a research focus for this route, since shifting immune behaviour is the most studied MSC property
- The procedure itself calls for sterile technique, an experienced clinician and the readiness to manage complications, which is why it is planned rather than offered casually
- The route is chosen for the goal, not because it is closer to the target: no route is presented here as clinically superior to another
Stem cells and exosomes are different.
One is a living cell. The other is a cell-derived messenger. The difference shapes how each is sourced, how it is given, and which one our medical team may propose for your case.

- 01 / SOURCE
Living source cells
Mesenchymal stromal cells are living cells. Their behavior depends on source, handling, dose, and biological context.
- 02 / SIGNAL
Released signals
Cells release soluble factors and extracellular vesicles. Exosomes are one subset of these small vesicles.
- 03 / RESPONSE
Local cell response
Nearby cells may respond to those signals. That biological rationale is where treatment planning starts, not a promise of a result.
Your case review
How Our Medical Team Assesses Suitability
The purpose of the review is clarity. Your diagnosis, medical history, reports, imaging, current medication and the goals that matter to you give our team the context to plan treatment, or to tell you that this route is not right for your case.
- A confirmed neurological diagnosis with recent specialist assessment and imaging our medical team can review
- Patients who are continuing their established neurological care and rehabilitation alongside treatment
- Spinal anatomy, bleeding risk, anticoagulant medication and infection status assessed as suitable for a lumbar puncture
- Ability to lie flat afterwards and to stay in Istanbul for the observation period the plan sets out
- Suitability is confirmed after our team reviews pressure inside the skull, current medication and the other contraindications to this route
Setting Realistic Goals for Your Treatment
Before treatment we agree on what we are aiming for: measures that fit your condition, a realistic period over which to review them, and what would count as no meaningful change. Goals are not predictions. Responses vary between patients and no clinical outcome can be guaranteed.
- The goal is written down before the procedure using validated measures for the diagnosis, so any change is compared against a recorded baseline
- Rehabilitation and established neurological care continue throughout; nothing in the plan replaces them
- Review points are set individually, and include watching for delayed effects as well as for change in the measures agreed
- What was given, when and with what monitoring is sent to your own neurologist so your care stays joined up
- Regenerative medicine is planned individually: responses vary between patients, no clinical outcome can be guaranteed, suitability is confirmed only after medical review, and treatment is planned alongside your existing care
Your next step
Find out whether intrathecal stem cell therapy may suit your case
If intrathecal stem cell therapy looks relevant to your diagnosis, the next step is a review of your own records by our medical team. If it does not, we can explain which of the other routes we plan may fit better.
Suitability is confirmed only after our medical team has reviewed your records, and treatment is planned alongside the care you already receive.
From Your Records to an Agreed Treatment Plan
How our team moves from your first records review to a plan you can act on: evidence, risk, practical detail and follow-up, settled before you travel.
Send your medical records
Recent reports, imaging, your current medication, and what you hope treatment will help with. It lets our medical team make the review specific to you.
Start your case reviewSend your medical records
Our patient coordination team starts with your confirmed diagnosis, recent reports and imaging, current medications, previous procedures, and the outcomes that matter most to you.
Medical case review
Our medical team reads the file and decides whether this pathway is relevant to your case, which route would suit it, and where your existing care should stay in the lead.
Read your written treatment plan
You receive the biological material proposed and its documentation, the preparation and dose, the route, the schedule, the monitoring, the risks, the alternatives, and an itemized cost, in writing.
Plan your treatment in Istanbul
We confirm appointment timing, how long to stay, airport transfers, accommodation, mobility needs, medication instructions and your local contact before you book travel.
Stay in contact after you go home
Before treatment we agree what will be measured, when it will be reviewed, who answers your questions once you are home, and how your own clinician is kept informed.
Intrathecal Stem Cell Therapy - Frequently Asked Questions
Does an intrathecal injection hurt?
Local anaesthetic is used, and most patients describe pressure rather than sharp pain. Headache, back pain or discomfort can follow, which is why you rest flat and are observed before discharge and given written instructions for what to do at home.
Who performs the procedure in Istanbul?
A physician experienced in lumbar puncture, working under sterile technique in a clinical setting with monitoring available. Your plan names the clinician responsible and describes the consent, anaesthesia and aftercare arrangements before you travel.
Why would your team propose this route rather than an infusion?
Because the goal is neurological and the fluid reached by a lumbar puncture is already in contact with the brain and spinal cord. It is a route selected for a type of goal, and our medical team will tell you when an intravenous or intranasal plan is the more sensible option for your case.
What are the risks?
Headache after the procedure is the most common, and there are risks of back pain, bleeding, infection and nerve irritation, along with the effects that can follow any cell preparation. Your plan lists them, our team explains what we do to reduce each one, and you are given emergency contact details.
Can it be combined with an intravenous infusion?
Sometimes both are planned, and sometimes one is enough. Our medical team explains what each part is there for, prices them separately, and is clear that you can decline either without losing the rest of the plan.
How soon can I travel after the procedure?
You stay in Istanbul for the observation period and any rest our team advises afterwards. Written fit-to-travel guidance is given once you have been reviewed, and your schedule should allow for it before you book a return flight.
How do I find out whether I may be suitable for treatment in Istanbul?
Send your confirmed diagnosis, recent reports and imaging, current medications and medical history to our patient coordination team. Our medical team reviews suitability case by case and tells you in writing whether this pathway fits your situation, and what it would involve.
How long do international patients stay in Istanbul?
It depends on the plan our medical team proposes: the procedure, the route, the monitoring, your mobility and the follow-up all affect it. Your written schedule states the number of days before you book flights or accommodation.
Is this treatment safe?
No medical treatment is free of risk, and we are direct about that. Our team reduces the risks that can be reduced: screened donor material, batch testing before release, administration by a physician in a clinical setting, monitoring during and after the procedure, and a written account of the side effects and contraindications that apply to your plan.
What results can I expect?
Your plan states a therapeutic goal and how it will be measured, not a promised outcome. Our medical team explains what change would be meaningful in your case, when it will be reviewed, and what we would do next if that review shows no benefit.
How much does treatment cost in Istanbul?
Pricing is case-specific: the material, the preparation and dose, the route, the number of sessions, the monitoring and any travel services all affect it. Our patient coordination team sends an itemized written estimate so you can see what each part of the plan costs before you commit.
What does the international patient program include?
Your estimate lists the medical review, tests, the procedure itself, monitoring, medications, airport transfers, accommodation arrangements, written discharge information and follow-up as separate lines, so you can see what is included and what is not.
How this guide is maintained
How This Guide Is Written and Reviewed
Editorial reviewHow this guide is reviewed
This guide carries a last-reviewed date. Review asks whether the way we describe intrathecal stem cell therapy and the research behind it still matches the published literature.
Where the evidence is limited, mixed or still emerging, the page says so rather than settling the question in the treatment's favour.
SourcingWhat we count as a source
Peer-reviewed human studies, trial registry entries and regulatory guidance. Laboratory and animal work is labelled as preclinical, and individual case reports are described as case reports.
Marketing material, including our own, is not treated as evidence.
Your treatment planWhat our medical team sets out
Before you agree to anything, our team can set out in writing the material proposed for your plan, how it is sourced, processed and release-tested, the route of administration, the monitoring plan, the full cost with exclusions, and who is clinically responsible for your care.
If any part of that is unclear, ask us. Your plan should make sense to you before you travel.

Sunrise from Istanbul's Asian shore, looking across the water. It shows the city you would travel to, not our clinic, your accommodation, or a service included in a plan.
Build recovery time around a lumbar procedure
We go through the preparation, the lumbar procedure, monitoring, headache and infection risk, mobility support, the recovery window, and follow-up before you book travel.
Keep researching
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More from our clinic
Planning your intrathecal stem cell therapy in Istanbul
The practical side of treatment at our clinic: what the research shows, who may be suitable, what a plan costs, and how your stay in Istanbul and your follow-up are arranged.
Cost, Outcomes & Istanbul
- Visit our Istanbul clinicWhere we are, how patients reach us, and what to arrange before you travel.
- Understand treatment pricingWhat shapes a quote, and what an itemized estimate from our clinic covers.
- Planning your Istanbul treatment tripRecords, travel timing, local transport, accommodation, and follow-up after you fly home.
- Choosing a stem cell clinic in IstanbulHow we document candidacy, pricing, clinical oversight, and aftercare for international patients.
- Rules and oversight in TurkeyHow regenerative medicine is regulated in Türkiye, and the paperwork that accompanies treatment.
- Reading stem cell success ratesWhat a published percentage can and cannot tell you about your own diagnosis.
- What your treatment quote includesWhat the clinical fee covers, which items are listed separately, and what moves the total.
- What to expect during treatmentThe remote case review, your written plan, the treatment day, and follow-up once you are home.
- Longevity and healthy-ageing care in IstanbulWhat our longevity programme assesses, and how it differs from treating a diagnosed condition.
- What exosome treatment in Istanbul costsHow we structure an exosome quote, and the line items a written estimate names.
- Exosome therapy questions we are askedSourcing, dosing, regulation, and the documentation that accompanies a proposed treatment.
- Medical travel to Turkey: patient guideHow remote record reviews, clinic scheduling, and travel logistics fit together.
- Comparing treatment abroad: Turkey vs MexicoQuestions to ask when comparing clinics, cell documentation, and oversight across countries.
Condition guides
Treatments & the science
- Stem Cell Therapy Overview
- Introduction to Stem Cell Therapy
- Umbilical Cord Stem Cells (UC-MSCs)
- Mesenchymal Stem Cell (MSC) Therapy
- How Stem Cells Work
- Safety & Treatment Process
- Exosome Therapy Overview
- How Exosomes Work
- Stem Cells vs Exosomes
- Intravenous (IV) Stem Cell Therapy
- Intrathecal Stem Cell Therapy
- Longevity Program
- See all treatments →
International patient support
Talk to our medical team about Intrathecal Stem Cell Therapy.
Send your diagnosis, reports, imaging and current medication. Our medical team explains which options may fit your case, what the treatment involves, and what your stay in Istanbul would look like.
Nothing needs to be booked to begin. Our patient coordination team plans your visit to Istanbul once your treatment plan is agreed.


